The vitamin D receptor (VDR) is a indivisible transcription point that is turned on by the presence of calcitriol. It forms a heterodimer with retinoid X and next enters the nucleus exactly where it binds to certain DNA sequences called Vitamin D responsive elements.
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In mammals, the VDR plays a pivotal role in the curly hair cycle, and loss of the receptor is usually associated with hair loss. It is important for the induction of postnatal locks cycle pathways and for the regulation of postmorphogenic hair cycle path ways. The VDR is expressed in the gut, the thyroid, the kidney, and numerous types of resistant cells.
Many myeloid leukemia cell lines express the VDR, but at numerous levels. Within a study of HL-60 cellular material, a chemical called one particular, 25(OH)2D3 (10-7 M) lowered the VDR necessary protein level by 50% within 24 hours. Following 72 hours, VDR protein amounts returned to normal. However , the drug would not affect the higher level of VDR mRNA or protein expression.
While VDR can be expressed in many neurons, additionally it is found in glial cells and a subset of real human primary glioblastoma skin cells. The protein has been immunoreactive in oligodendrocytes of the white matter. Furthermore, VDR has been detected in glial fibrillary acid protein.